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Semiconducting Polymer Nanoenzymes with Photothermic Activity for Enhanced Cancer Therapy
Author(s) -
Li Jingchao,
Xie Chen,
Huang Jiaguo,
Jiang Yuyan,
Miao Qingqing,
Pu Kanyi
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201800511
Subject(s) - photothermal therapy , cancer therapy , extracellular matrix , radiation therapy , cancer , enzyme , enzyme assay , nanotechnology , cancer cell , biophysics , cancer research , materials science , chemistry , medicine , biochemistry , biology
Regulation of enzyme activity is fundamentally challenging but practically meaningful for biology and medicine. However, noninvasive remote control of enzyme activity in living systems has been rarely demonstrated and exploited for therapy. Herein, we synthesize a semiconducting polymer nanoenzyme with photothermic activity for enhanced cancer therapy. Upon near‐infrared (NIR) light irradiation, the activity of the nanoenzyme can be enhanced by 3.5‐fold to efficiently digest collagen in the tumor extracellular matrix (ECM), leading to enhanced nanoparticle accumulation in tumors and consequently improved photothermal therapy (PTT). This study thus provides a promising strategy to remotely regulate enzyme activity for cancer therapy.