Premium
Access to Enantioenriched Organosilanes from Enals and β‐Silyl Enones: Carbene Organocatalysis
Author(s) -
Zhang Yuxia,
Huang Jie,
Guo Yingying,
Li Lin,
Fu Zhenqian,
Huang Wei
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201800483
Subject(s) - organocatalysis , carbene , silylation , chemistry , organic chemistry , catalysis , enantioselective synthesis
Herein, an efficient route to enantioenriched organosilanes, containing two consecutive stereogenic centers, from enals and β‐silyl enones under carbene organocatalysis is described. Under mild reaction conditions, this transition‐metal‐free strategy exhibits a broad substrate scope, and excellent diastereo‐ and enantioselectivity.