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Hydrophilicity Regulates the Stealth Properties of Polyphosphoester‐Coated Nanocarriers
Author(s) -
Simon Johanna,
Wolf Thomas,
Klein Katja,
Landfester Katharina,
Wurm Frederik R.,
Mailänder Volker
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201800272
Subject(s) - nanocarriers , protein adsorption , ethylene glycol , polymer , peg ratio , adsorption , copolymer , chemistry , chemical engineering , biophysics , blood proteins , materials science , polymer chemistry , drug delivery , organic chemistry , biochemistry , finance , engineering , economics , biology
Increasing the plasma half‐life is an important goal in the development of drug carriers, and can be effectively achieved through the attachment of polymers, in particular poly(ethylene glycol) (PEG). While the increased plasma half‐life has been suggested to be a result of decreased overall protein adsorption on the hydrophilic surface in combination with the adsorption of specific proteins, the molecular reasons for the success of PEG and other hydrophilic polymers are still widely unknown. We prepared polyphosphoester‐coated nanocarriers with defined hydrophilicity to control the stealth properties of the polymer shell. We found that the log P value of the copolymer controls the composition of the protein corona and the cell interaction. Upon a significant change in hydrophilicity, the overall amount of blood proteins adsorbed on the nanocarrier remained unchanged, while the protein composition varied. This result underlines the importance of the protein type for the protein corona and cellular uptake.