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Back Cover: Artificial Cysteine S‐Glycosylation Induced by Per‐O‐Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling (Angew. Chem. Int. Ed. 7/2018)
Author(s) -
Qin Wei,
Qin Ke,
Fan Xinqi,
Peng Linghang,
Hong Weiyao,
Zhu Yuntao,
Lv Pinou,
Du Yifei,
Huang Rongbing,
Han Mengting,
Cheng Bo,
Liu Yuan,
Zhou Wen,
Wang Chu,
Chen Xing
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201800116
Subject(s) - glycosylation , monosaccharide , glycan , chemistry , cysteine , acetylation , biochemistry , cover (algebra) , stereochemistry , glycoprotein , engineering , mechanical engineering , gene , enzyme
Peracetylated unnatural sugars the “arrows” used by glycoscientists for decades to label cellular glycans, can induce artificial cysteine glycosylation on various proteins, as reported in the Communication on page 1817 ff. by C. Wang, X. Chen et al. This “off‐targeting” of the per‐O‐acetylated sugar reporters can be likened to Cao Cao shooting arrows at scarecrows and straw boats in the fictitious story “Romance of the Three Kingdoms”, and calls for caution in the use of peracetylated sugars and the development of better versions.