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Inside Back Cover: Dynamic Cross‐Exchange in Halophosphonium Species: Direct Observation of Stereochemical Inversion in the Course of an S N 2 Process (Angew. Chem. Int. Ed. 6/2018)
Author(s) -
Nikitin Kirill,
Jennings Elizabeth V.,
Al Sulaimi Sulaiman,
Ortin Yannick,
Gilheany Declan G.
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201800026
Subject(s) - sn2 reaction , inversion (geology) , halide , chemistry , nucleophile , crystallography , stereochemistry , organic chemistry , geology , paleontology , structural basin , catalysis
Unlike an unruly brolly or the striking lily of the Nile, the celebrated umbrella‐like S N 2 inversion has not been directly observed until now. In their Communication on page 1480 ff., K. Nikitin, D. G. Gilheany, et al. demonstrate direct observation of inversion in a low‐temperature NMR‐EXSY experiment using an inseparable mixture of isomers. Fast nucleophilic attack of a halide ion on a phosphonium center has all the characteristics of an associative process and leads to inversion of the P configuration.