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Frontispiece: Characterization of Giant Modular PKSs Provides Insight into Genetic Mechanism for Structural Diversification of Aminopolyol Polyketides
Author(s) -
Zhang Lihan,
Hashimoto Takuya,
Qin Bin,
Hashimoto Junko,
Kozone Ikuko,
Kawahara Teppei,
Okada Masahiro,
Awakawa Takayoshi,
Ito Takuya,
Asakawa Yoshinori,
Ueki Masashi,
Takahashi Shunji,
Osada Hiroyuki,
Wakimoto Toshiyuki,
Ikeda Haruo,
Shinya Kazuo,
Abe Ikuro
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201780761
Subject(s) - polyketide , biology , phylogenetic tree , gene , mechanism (biology) , genetics , diversification (marketing strategy) , computational biology , biosynthesis , philosophy , epistemology , marketing , business
Polyketide Biosynthesis : Aminopolyols are biosynthesized by polyketide synthases (PKSs). In their Communication on page 1740 I. Abe et al. show that heterologous expression of over 150 kbp PKS gene clusters afforded novel aminopolyols. Phylogenetic comparison of four aminopolyol PKS gene clusters showed the mechanism of PKS reprogramming in nature.