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KCa(H 2 O) 2 [Fe III (CN) 6 ]⋅H 2 O Nanoparticles as an Antimicrobial Agent against Staphylococcus aureus
Author(s) -
Wang Zhongxia,
Yu Bing,
Alamri Huda,
Yarabarla Sriramakrishna,
Kim MinHo,
Huang Songping D.
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201713177
Subject(s) - prussian blue , staphylococcus aureus , intracellular , chemistry , nanoparticle , ion exchange , nuclear chemistry , antimicrobial , bacteria , membrane , cell membrane , bacterial cell structure , ion , biophysics , inorganic chemistry , nanotechnology , biochemistry , materials science , organic chemistry , biology , electrode , electrochemistry , genetics
Biocompatible nanoparticles based on a calcium analogue of Prussian blue were designed and synthesized to take advantage of their ability to penetrate the cell membrane in Staphylococcus aureus and to undergo selective ion exchange with intracellular iron to disrupt iron metabolism in such pathogenic bacteria for antibacterial applications. KCa(H 2 O) 2 [Fe III (CN) 6 ]⋅H 2 O nanoparticles penetrate the bacterial cell membrane and sequester intracellular iron by ion exchange to form insoluble Prussian blue, thus inhibiting bacterial growth.