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Absolute Configuration of Pharmaceutical Research Compounds Determined by X‐ray Powder Diffraction
Author(s) -
Schlesinger Carina,
Tapmeyer Lukas,
Gumbert Silke D.,
Prill Dragica,
Bolte Michael,
Schmidt Martin U.,
Saal Christoph
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201713168
Subject(s) - active ingredient , absolute configuration , counterion , powder diffraction , diffraction , chirality (physics) , materials science , crystallography , chemistry , nanotechnology , stereochemistry , organic chemistry , optics , physics , ion , chiral symmetry , bioinformatics , nambu–jona lasinio model , biology , quark , quantum mechanics
The absolute configuration of active pharmaceutical ingredients (APIs) was determined by generating salts of the active pharmaceutical ingredient (API) with counterions of known chirality, and determining the crystal structures by X‐ray powder diffraction. This approach avoids the (often tedious) growth of single crystals, and is successful with very limited quantities of material (less than 1 mg). The feasibility of the method is demonstrated on five examples, and its limitations are discussed as well.