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Towards Sequence‐Controlled Antimicrobial Polymers: Effect of Polymer Block Order on Antimicrobial Activity
Author(s) -
Judzewitsch Peter R.,
Nguyen ThuyKhanh,
Shanmugam Sivaprakash,
Wong Edgar H. H.,
Boyer Cyrille
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201713036
Subject(s) - antimicrobial , raft , polymer , monomer , chain transfer , copolymer , combinatorial chemistry , chemistry , sequence (biology) , materials science , organic chemistry , radical polymerization , biochemistry
Synthetic polymers have shown promise in combating multidrug‐resistant bacteria. However, the biological effects of sequence control in synthetic antimicrobial polymers are currently not well understood. As such, we investigate the antimicrobial effects of monomer distribution within linear high‐order quasi‐block copolymers consisting of aminoethyl, phenylethyl, and hydroxyethyl acrylamides made in a one‐pot synthesis approach via photoinduced electron transfer–reversible addition–fragmentation chain transfer polymerisation (PET‐RAFT). Through different combinations of monomer/polymer block order, antimicrobial and haemolytic activities are tuneable in a manner comparable to antimicrobial peptides.