A Monoaryllead Trichloride That Resists Reductive Elimination | Zendy

Olaru Marian | Zendy; Kather Ralf | Zendy; Hupf Emanuel | Zendy; Lork Enno | Zendy; Mebs Stefan | Zendy; Beckmann Jens | Zendy

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A Monoaryllead Trichloride That Resists Reductive Elimination

Author(s) -

Olaru Marian,

Kather Ralf,

Hupf Emanuel,

Lork Enno,

Mebs Stefan,

Beckmann Jens

Publication year - 2018

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201712944

Subject(s) - transmetalation , chemistry , substituent , trihalide , reductive elimination , resist , medicinal chemistry , stereochemistry , combinatorial chemistry , catalysis , inorganic chemistry , organic chemistry , layer (electronics) , halide

Abstract Transmetallation of Pb(OAc) 4 with R 2 Hg ( 1 ), followed by treatment with HCl in Et 2 O, provided RPbCl 3 ( 2 ), the first kinetically stabilized monoorganolead trihalide that resists reductive elimination under ambient conditions. The kinetic stabilisation relies on an intramolecularly coordinating O‐donor substituent ( R =6‐Ph 2 P(O)‐Ace‐5‐). The gram‐scale preparation of 2 was key for the synthesis of unsymmetrically substituted diaryllead dichlorides RR′PbCl 2 ( 3 a , R′=Ph; 3 b , R′=4‐MeOC 6 H 4 ; 3 c , R′=4‐Me 2 NC 6 H 4 ).

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