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A Monoaryllead Trichloride That Resists Reductive Elimination
Author(s) -
Olaru Marian,
Kather Ralf,
Hupf Emanuel,
Lork Enno,
Mebs Stefan,
Beckmann Jens
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201712944
Subject(s) - transmetalation , chemistry , substituent , trihalide , reductive elimination , resist , medicinal chemistry , stereochemistry , combinatorial chemistry , catalysis , inorganic chemistry , organic chemistry , layer (electronics) , halide
Transmetallation of Pb(OAc) 4 with R 2 Hg ( 1 ), followed by treatment with HCl in Et 2 O, provided RPbCl 3 ( 2 ), the first kinetically stabilized monoorganolead trihalide that resists reductive elimination under ambient conditions. The kinetic stabilisation relies on an intramolecularly coordinating O‐donor substituent ( R =6‐Ph 2 P(O)‐Ace‐5‐). The gram‐scale preparation of 2 was key for the synthesis of unsymmetrically substituted diaryllead dichlorides RR′PbCl 2 ( 3 a , R′=Ph; 3 b , R′=4‐MeOC 6 H 4 ; 3 c , R′=4‐Me 2 NC 6 H 4 ).