Premium
An Intracellular H 2 O 2 ‐Responsive AIEgen for the Peroxidase‐Mediated Selective Imaging and Inhibition of Inflammatory Cells
Author(s) -
Cheng Yong,
Dai Jun,
Sun Chunli,
Liu Rui,
Zhai Tianyou,
Lou Xiaoding,
Xia Fan
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201712803
Subject(s) - aggregation induced emission , myeloperoxidase , chemistry , intracellular , peroxidase , apoptosis , cancer cell , tyrosine , enzyme , cell , biochemistry , microbiology and biotechnology , inflammation , biophysics , cancer , biology , fluorescence , immunology , physics , genetics , quantum mechanics
Abstract Inflammatory cells have gained widespread attention because inflammatory diseases increase the risk for many types of cancer. Therefore, it is urgent and important to implement detection and treatment methods for inflammatory cells. Herein, we constructed a theranostic probe with aggregation‐induced emission (AIE) characteristics, in which tetraphenylethene (TPE) was modified with two tyrosine (Tyr) moieties. Owing to the H 2 O 2 ‐dependent, enzyme‐catalyzed dityrosine formation, Tyr‐containing TPE ( TT ) molecules crosslink through dityrosine linkages to induce the formation of hydrophobic aggregates, activating the AIE process in inflammatory cells that contain H 2 O 2 and overexpress myeloperoxidase. The emission turn‐on resulting from the crosslinking of TT molecules could be used to distinguish between inflammatory and normal cells. Moreover, the massive TT aggregates induced mitochondria damage and cell apoptosis. This study demonstrates that the H 2 O 2 ‐responsive peroxidase‐activated AIEgen holds great promise for inflammatory‐cell selective imaging and inhibition.