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Catalytic Enantioselective Aza‐Benzoin Reactions of Aldehydes with 2 H ‐Azirines
Author(s) -
Peng Qiupeng,
Guo Donghui,
Bie Jianbo,
Wang Jian
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201712785
Subject(s) - enantioselective synthesis , benzoin , carbene , catalysis , optically active , chemistry , organic chemistry , combinatorial chemistry
Abstract The unprecedented enantioselective aza‐benzoin reaction of aldehydes with 2 H ‐azirines was developed by utilizing a chiral N‐heterocyclic carbene as the catalyst. A wide range of corresponding aziridines can be obtained in good yields with high enantioselectivities. The obtained optically active aziridines should be useful in the synthesis of other valuable molecules.