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Enantioselective Iridium‐Catalyzed Phthalide Formation through Internal Redox Allylation of Phthalaldehydes
Author(s) -
Cabrera James M.,
Tauber Johannes,
Krische Michael J.
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201712015
Subject(s) - phthalide , enantioselective synthesis , redox , catalysis , chemistry , ether , iridium , combinatorial chemistry , organic chemistry
An inside job : Enantioselective phthalide synthesis was achieved through internal redox allylation of o ‐phthalaldehydes. Oxidative esterification is balanced by reductive carbonyl addition to achieve an overall redox‐neutral process. This method enabled formal syntheses of ent ‐spirolaxine methyl ether and CJ‐12,954.

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