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Fuel‐Selective Transient Activation of Nanosystems for Signal Generation
Author(s) -
della Sala Flavio,
Maiti Subhabrata,
Bonanni Andrea,
Scrimin Paolo,
Prins Leonard J.
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201711964
Subject(s) - selectivity , transient (computer programming) , nanoparticle , monolayer , chemistry , signal (programming language) , nanotechnology , combinatorial chemistry , materials science , computer science , organic chemistry , catalysis , programming language , operating system
Abstract The transient activation of function using chemical fuels is common in nature, but much less in synthetic systems. Progress towards the development of systems with a complexity similar to that of natural ones requires chemical fuel selectivity. Here, we show that a self‐assembled nanosystem, composed of monolayer‐protected gold nanoparticles and a fluorogenic peptide, is activated for transient signal generation only in case the chemical fuel matches the recognition site present at the nanoparticle surface. A modification of the recognition site in the nanosystem completely changes the chemical fuel selectivity. When two nanosystems are simultaneously present, the selectivity expressed by the system depends on the concentration of nucleotide added.