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Electrochemical Synthesis of Imidazo‐Fused N‐Heteroaromatic Compounds through a C−N Bond‐Forming Radical Cascade
Author(s) -
Hou ZhongWei,
Mao ZhongYi,
Melcamu Yared Yohannes,
Lu Xin,
Xu HaiChao
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201711876
Subject(s) - electrosynthesis , annulation , oxidizing agent , catalysis , combinatorial chemistry , electrochemistry , reagent , chemistry , substrate (aquarium) , cascade , transition metal , organic chemistry , electrode , oceanography , geology , chromatography
We have developed a unified strategy for preparing a variety of imidazo‐fused N‐heteroaromatic compounds through regiospecific electrochemical (3+2) annulation reaction of heteroarylamines with tethered internal alkynes. The electrosynthesis employs a novel tetraarylhydrazine as the catalyst, has a broad substrate scope, and obviates the need for transition‐metal catalysts and oxidizing reagents.