(Radio)fluoroclick Reaction Enabled by a Hydrogen‐Bonding Cluster | Zendy

Zeng Xiaojun | Zendy; Li Junling | Zendy; Ng Chin K. | Zendy; Hammond Gerald B. | Zendy; Xu Bo | Zendy

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(Radio)fluoroclick Reaction Enabled by a Hydrogen‐Bonding Cluster

Author(s) -

Zeng Xiaojun,

Li Junling,

Ng Chin K.,

Hammond Gerald B.,

Xu Bo

Publication year - 2018

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201711341

Subject(s) - chemistry , nucleophile , cluster (spacecraft) , functional group , hydrogen bond , atmosphere (unit) , hydrogen , group (periodic table) , combinatorial chemistry , molecule , organic chemistry , catalysis , computer science , operating system , physics , polymer , thermodynamics

We have developed a widely applicable nucleophilic (radio)fluoroclick reaction of ynamides with readily available and easy‐to‐handle KF( 18 F). The reactions exhibited high functional‐group tolerance and needed only an ambient atmosphere. This 18 F addition to C−C unsaturated bonds proceeded with extraordinarily high radiochemical yields.

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