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(Radio)fluoroclick Reaction Enabled by a Hydrogen‐Bonding Cluster
Author(s) -
Zeng Xiaojun,
Li Junling,
Ng Chin K.,
Hammond Gerald B.,
Xu Bo
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201711341
Subject(s) - chemistry , nucleophile , cluster (spacecraft) , functional group , hydrogen bond , atmosphere (unit) , hydrogen , group (periodic table) , combinatorial chemistry , molecule , organic chemistry , catalysis , computer science , operating system , physics , polymer , thermodynamics
We have developed a widely applicable nucleophilic (radio)fluoroclick reaction of ynamides with readily available and easy‐to‐handle KF( 18 F). The reactions exhibited high functional‐group tolerance and needed only an ambient atmosphere. This 18 F addition to C−C unsaturated bonds proceeded with extraordinarily high radiochemical yields.