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Catalytic Direct‐Type Addition Reactions of Alkylarenes with Imines and Alkenes
Author(s) -
Yamashita Yasuhiro,
Suzuki Hirotsugu,
Sato Io,
Hirata Tsubasa,
Kobayashi Shū
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201711291
Subject(s) - chemistry , catalysis , toluene , stereoselectivity , reaction conditions , organic chemistry , addition reaction , combinatorial chemistry
Catalytic addition reactions of very weakly acidic nonactivated alkylarenes such as toluene and its derivatives were developed by using a strongly basic mixed catalyst system under mild reaction conditions. The addition reactions with imines and alkenes proceeded smoothly under proton‐transfer conditions to afford the desired products in good to high yields, and high levels of regio‐ and stereoselectivity were achieved. It was also revealed that the asymmetric addition reaction of an alkylarene was possible.