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Ultrasensitive Chemiluminescent Detection of Cathepsin B: Insights into the New Frontier of Chemiluminescent Imaging
Author(s) -
Ryan Lucas S.,
Lippert Alexander R.
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201711228
Subject(s) - chemiluminescence , chemistry , cathepsin b , detection limit , sensitivity (control systems) , chromatography , biochemistry , enzyme , electronic engineering , engineering
Let there be light : Chemiluminescence provides a bright detection signal against a dark background and offers an excellent signal‐to‐noise ratio for analysis. Now, a chemiluminescent probe for cathepsin B has been developed that provides a 16,000‐fold improvement in sensitivity for detecting protease activity.
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