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Atropoenantioselective Redox‐Neutral Amination of Biaryl Compounds through Borrowing Hydrogen and Dynamic Kinetic Resolution
Author(s) -
Zhang Jianwei,
Wang Jian
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201711126
Subject(s) - kinetic resolution , amination , chemistry , combinatorial chemistry , redox , reductive amination , catalysis , substrate (aquarium) , functional group , enantioselective synthesis , organic chemistry , oceanography , polymer , geology
We report herein a novel atropoenantioselective redox‐neutral amination of biaryl compounds triggered by a cascade of borrowing hydrogen and dynamic kinetic resolution under the cooperative catalysis of a chiral iridium complex and an achiral Brønsted acid. This protocol features broad substrate scope and good functional‐group tolerance, and allows the rapid assembly of axially chiral biaryl compounds in good to high yields and with high to excellent enantioselectivity.