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Inside Cover: Organoiridium Photosensitizers Induce Specific Oxidative Attack on Proteins within Cancer Cells (Angew. Chem. Int. Ed. 47/2017)
Author(s) -
Zhang Pingyu,
Chiu Cookson K. C.,
Huang Huaiyi,
Lam Yuko P. Y.,
Habtemariam Abraha,
Malcomson Thomas,
Paterson Martin J.,
Clarkson Guy J.,
O'Connor Peter B.,
Chao Hui,
Sadler Peter J.
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201710973
Subject(s) - photodynamic therapy , cover (algebra) , cancer cell , int , reactive oxygen species , chemistry , cancer , cancer research , biophysics , biochemistry , biology , computer science , genetics , mechanical engineering , organic chemistry , engineering , operating system
Photodynamic therapy can be used to introduce novel mechanisms of killing cancer cells that overcome resistance. In their Communication on page 14898 ff., P. B. O'Connor, H. Chao, P. J. Sadler et al. describe luminescent organoiridium complexes, with long‐lived excited states, which selectively damage cancer cells upon activation by two‐photon red light, thus producing oxygen which attacks key cellular proteins (cover art by Juanjuan Huang).