Cobalt‐Catalyzed Electrophilic Amination of Aryl‐ and Heteroarylzinc Pivalates with  N ‐Hydroxylamine Benzoates | Zendy

Chen YiHung | Zendy; Graßl Simon | Zendy; Knochel Paul | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Cobalt‐Catalyzed Electrophilic Amination of Aryl‐ and Heteroarylzinc Pivalates with N ‐Hydroxylamine Benzoates

Author(s) -

Chen YiHung,

Graßl Simon,

Knochel Paul

Publication year - 2018

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201710931

Subject(s) - amination , electrophilic amination , aryl , chemistry , cobalt , benzoates , electrophile , yield (engineering) , hydroxylamine , catalysis , organic chemistry , medicinal chemistry , combinatorial chemistry , alkyl , materials science , metallurgy

Aryl‐ and heteroarylzinc pivalates can be aminated with O ‐benzoylhydroxylamines at 25 °C within 2–4 h in the presence of 2.5–5.0 % CoCl 2 ⋅2 LiCl to furnish the corresponding tertiary arylated or heteroarylated amines in good yields. This electrophilic amination also provides access to diarylamines and aryl(heteroaryl)amines. A new tuberculosis drug candidate (Q203) was prepared in six steps and 56 % overall yield by using this cobalt‐catalyzed amination as the key step.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research