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Photocontrolled Release of Chemicals from Nano‐ and Microparticle Containers
Author(s) -
Englert Christoph,
Nischang Ivo,
Bader Cornelia,
Borchers Philipp,
Alex Julien,
Pröhl Michael,
Hentschel Martin,
Hartlieb Matthias,
Traeger Anja,
Pohnert Georg,
Schubert Stephanie,
Gottschaldt Michael,
Schubert Ulrich S.
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201710756
Subject(s) - polyester , microparticle , nano , polymer , materials science , nanotechnology , biocompatibility , chemical engineering , chemistry , organic chemistry , composite material , engineering
A benzoin‐derived diol linker was synthesized and used to generate biocompatible polyesters that can be fully decomposed on demand upon UV irradiation. Extensive structural optimization of the linker unit was performed to enable the defined encapsulation of diverse organic compounds in the polymeric structures and allow for a well‐controllable polymer cleavage process. Selective tracking of the release kinetics of encapsulated model compounds from the polymeric nano‐ and microparticle containers was performed by confocal laser scanning microscopy in a proof‐of‐principle study. The physicochemical properties of the incorporated and released model compounds ranged from fully hydrophilic to fully hydrophobic. The demonstrated biocompatibility of the utilized polyesters and degradation products enables their use in advanced applications, for example, for the smart packaging of UV‐sensitive pharmaceuticals, nutritional components, or even in the area of spatially selective self‐healing processes.