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Fluorine in a C−F Bond as the Key to Cage Formation
Author(s) -
Holl Maxwell Gargiulo,
Pitts Cody Ross,
Lectka Thomas
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201710423
Subject(s) - cage , non covalent interactions , fluorine , covalent bond , chemistry , reactivity (psychology) , molecule , ion , chemical physics , computational chemistry , hydrogen bond , organic chemistry , medicine , alternative medicine , mathematics , pathology , combinatorics
Cage molecules have long been employed to trap reactive or transient species, as their rigid nature allows them to enforce situations that otherwise would not persist. In this Minireview, we discuss our use of rigid cage structures to investigate the close noncovalent interactions of fluorine with other functional groups and determine how mutual proximity affects both physical properties and reactivity. Unusual covalent interactions of fluorine are also explored: the cage can close to form the first solution‐phase C‐F‐C fluoronium ion.