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Cobalt‐Catalyzed Diborylation of 1,1‐disubstituted Vinylarenes: A Practical Route to Branched gem ‐Bis(boryl)alkanes
Author(s) -
Teo Wei Jie,
Ge Shaozhong
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201710389
Subject(s) - xantphos , cobalt , catalysis , chemistry , medicinal chemistry , organic chemistry , combinatorial chemistry , polymer chemistry , palladium
Abstract We report the first catalytic diborylation of 1,1‐disubstituted vinylarenes with pinacolborane using a cobalt catalyst generated from bench‐stable Co(acac) 2 and xantphos. A wide range of 1,1‐disubstituted vinylarenes underwent this transformation to produce the corresponding gem ‐bis(boryl)alkanes in modest to high yields. This cobalt‐catalyzed reaction can be readily conducted on a gram scale without the use of a dry box and represents a practical and effective approach to prepare a wide range of branched gem ‐bis(boryl)alkanes.