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Transition‐Metal‐Catalyzed Selective Functionalization of C(sp 3 )−H Bonds in Natural Products
Author(s) -
Karimov Rashad R.,
Hartwig John F.
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201710330
Subject(s) - surface modification , catalysis , natural product , inert , transition metal , molecule , chemistry , combinatorial chemistry , organic chemistry
Direct functionalization of natural products is important for studying the structure–activity and structure–property relationships of these molecules. Recent advances in the transition‐metal‐catalyzed functionalization of C(sp 3 )−H bonds, the most abundant yet inert bonds in natural products, have allowed natural product derivatives to be created selectively. Strategies to achieve such transformation are reviewed.