Premium
Site‐Selective O‐Arylation of Glycosides
Author(s) -
Shang Weidong,
Mou ZeDong,
Tang Hua,
Zhang Xia,
Liu Jie,
Fu Zhengyan,
Niu Dawen
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201710310
Subject(s) - scope (computer science) , selectivity , substrate (aquarium) , ligand (biochemistry) , combinatorial chemistry , chemistry , transformation (genetics) , copper , glycoside , catalysis , stereochemistry , organic chemistry , computer science , biochemistry , biology , receptor , ecology , gene , programming language
Direct and site‐selective O‐arylation of carbohydrates has been a challenge in synthesis. Herein we report a method based on copper‐catalyzed O‐arylation to address this challenge. Proper choice of the ancillary ligand on copper is critical for the efficiency and site selectivity of this transformation. This method features mild conditions, tolerates various functional groups, and demonstrates broad substrate scope.