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Ruthenium(II)‐Catalyzed Synthesis of Spirobenzofuranones by a Decarbonylative Annulation Reaction
Author(s) -
Kaishap Partha P.,
Duarah Gauri,
Sarma Bipul,
Chetia Dipak,
Gogoi Sanjib
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201710049
Subject(s) - annulation , alkyne , catalysis , chemistry , ruthenium , carbon monoxide , decarbonylation , ligand (biochemistry) , medicinal chemistry , combinatorial chemistry , organic chemistry , receptor , biochemistry
The first decarbonylative insertion of an alkyne through C−H/C−C activation of six‐membered compounds is reported. The Ru‐catalyzed reaction of 3‐hydroxy‐2‐phenyl‐chromones with alkynes works most efficiently in the presence of the ligand PPh 3 to provide spiro‐indenebenzofuranones. Unlike previously reported metal‐catalyzed decarbonylative annulation reactions, in the present decarbonylative annulation reaction, the annulation occurs before extrusion of carbon monoxide.
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