Premium
Selective Functionalization of Aromatic C(sp 2 )−H Bonds in the Presence of Benzylic C(sp 3 )−H Bonds by Electron‐Deficient Carbenoids Generated from 4‐Acyl‐1‐Sulfonyl‐1,2,3‐Triazoles
Author(s) -
Miura Tomoya,
Zhao Qiang,
Murakami Masahiro
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201709384
Subject(s) - rhodium , chemistry , benzene , surface modification , acceptor , sulfonyl , medicinal chemistry , electron deficiency , catalysis , stereochemistry , organic chemistry , physics , alkyl , condensed matter physics
A rhodium(II)‐catalyzed reaction of newly prepared 4‐acyl‐1‐sulfonyl‐1,2,3‐triazoles with benzene, and its derivatives, is investigated. Acceptor/acceptor carbenoids generated from 4‐acyltriazoles undergo selective insertion at aromatic C(sp 2 )−H bonds in the presence of benzylic C(sp 3 )−H bonds to produce N ‐sulfonylenaminones.