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Access to α‐Amino Acid Esters through Palladium‐Catalyzed Oxidative Amination of Vinyl Ethers with Hydrogen Peroxide as the Oxidant and Oxygen Source
Author(s) -
Ouyang Lu,
Li Jianxiao,
Zheng Jia,
Huang Jiuzhong,
Qi Chaorong,
Wu Wanqing,
Jiang Huanfeng
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201709285
Subject(s) - hydrogen peroxide , catalysis , chemistry , palladium , amination , organic chemistry , oxygen , peroxide , amino acid , combinatorial chemistry , biochemistry
A novel and convenient palladium catalytic system for the synthesis of α‐amino acid esters from simple starting materials is reported. Hydrogen peroxide not only acts as the green oxidant, but also as the oxygen source. This strategy for the conversion of amines and vinyl ethers into highly functionalized and structurally diverse α‐amino acid esters is characterized by the simplicity of the experimental procedure, mild reaction conditions, high atom economy, scalability, and practicability.