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Bifurcated Nickel‐Catalyzed Functionalizations: Heteroarene C−H Activation with Allenes
Author(s) -
Nakanowatari Sachiyo,
Müller Thomas,
Oliveira João C. A.,
Ackermann Lutz
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201709087
Subject(s) - chemoselectivity , catalysis , chemistry , nickel , ligand (biochemistry) , combinatorial chemistry , carbene , scope (computer science) , imidazole , catalytic cycle , purine , stereochemistry , organic chemistry , enzyme , computer science , biochemistry , receptor , programming language
A unified strategy for nickel(0)‐catalyzed C−H allylations, alkenylations, and dienylations has been realized through versatile hydroarylations of allenes with ample scope. Thus, an inexpensive nickel catalyst modified with a N ‐heterocyclic carbene ligand enabled the direct transformation of C−H bonds of biologically relevant imidazole and purine derivatives with full control of regio‐ and chemoselectivity.