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Nickel‐Catalyzed N‐Alkylation of Acylhydrazines and Arylamines Using Alcohols and Enantioselective Examples
Author(s) -
Yang Peng,
Zhang Caili,
Ma Yu,
Zhang Caiyun,
Li Aijie,
Tang Bo,
Zhou Jianrong Steve
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201708949
Subject(s) - enantioselective synthesis , alkylation , nickel , catalysis , chemistry , organic chemistry , combinatorial chemistry
A borrowing‐hydrogen reaction between amines and alcohols is an atom‐economic way to prepare alkylamines, ideally with water as the sole byproduct. Herein, nickel catalysts are used for direct N‐alkylation of hydrazides and arylamines using racemic alcohols. Moreover, a nickel catalyst of ( S )‐binapine was used for an asymmetric N‐alkylation of benzohydrazide with racemic benzylic alcohols.