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A Redox Modulatory Mn 3 O 4 Nanozyme with Multi‐Enzyme Activity Provides Efficient Cytoprotection to Human Cells in a Parkinson's Disease Model
Author(s) -
Singh Namrata,
Savanur Mohammed Azharuddin,
Srivastava Shubhi,
D'Silva Patrick,
Mugesh Govindasamy
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201708573
Subject(s) - cytoprotection , superoxide dismutase , catalase , antioxidant , chemistry , oxidative stress , glutathione peroxidase , enzyme , reactive oxygen species , biochemistry , parkinson's disease , glutathione , cytotoxicity , microbiology and biotechnology , biology , disease , medicine , in vitro , pathology
Nanomaterials with enzyme‐like activities (nanozymes) attracts significant interest due to their therapeutic potential for the treatment of various diseases. Herein, we report that a Mn 3 O 4 nanozyme functionally mimics three major antioxidant enzymes, that is, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) and the multienzyme activity is size as well as morphology‐dependent. The redox modulatory effect of Mn 3 O 4 plays a crucial role in protecting the cells from MPP+ induced cytotoxicity in a Parkinson disease (PD)‐like cellular model, indicating that manganese‐based nanomaterials having multi‐enzyme activity can robustly rescue the cells from oxidative damage and thereby possess therapeutic potential to prevent ROS‐mediated neurological disorders.