Premium
Inside Back Cover: Gold‐Triggered Uncaging Chemistry in Living Systems (Angew. Chem. Int. Ed. 41/2017)
Author(s) -
PérezLópez Ana M.,
RubioRuiz Belén,
Sebastián Víctor,
Hamilton Lloyd,
Adam Catherine,
Bray Thomas L.,
Irusta Silvia,
Brennan Paul M.,
LloydJones Guy C.,
Sieger Dirk,
Santamaría Jesús,
UncitiBroceta Asier
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201708379
Subject(s) - bioorthogonal chemistry , chemistry , cover (algebra) , nanotechnology , combinatorial chemistry , click chemistry , materials science , mechanical engineering , engineering
Thiols are ubiquitous in living systems where they bind strongly to gold surfaces and render interactions with other functional groups basically non‐existent. In their Communication on page 12548 ff., J. Santamaría and A. Unciti‐Broceta et al. describe heterogeneous gold catalysts that enable bioorthogonal uncaging (by O/N‐depropargylation) of clinically approved anticancer drugs in cancer cell culture, and the first intracranial activation of a bioorthogonal probe in a zebrafish.