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Synergistic Manganese(I) C−H Activation Catalysis in Continuous Flow: Chemoselective Hydroarylation
Author(s) -
Wang Hui,
Pesciaioli Fabio,
Oliveira João C. A.,
Warratz Svenja,
Ackermann Lutz
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201708271
Subject(s) - manganese , catalysis , chemistry , continuous flow , chemoselectivity , brønsted–lowry acid–base theory , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry , physics , mechanics
Chemoselective hydroarylations were accomplished by a novel synergistic Brønsted acid/manganese(I)‐catalyzed C−H activation manifold. Thus, alkynes bearing O‐leaving groups could, for the first time, be employed for C−H alkenylations without concurrent β‐O elimination, thereby setting the stage for versatile late‐stage diversifications. Also described is the first manganese‐catalyzed C−H activation in continuous flow, thus enabling efficient hydroarylations within only 20 minutes.