Selective Radical Fluorination of Tertiary Alkyl Halides at Room Temperature | Zendy

Chen He | Zendy; Liu Zhonglin | Zendy; Lv Ying | Zendy; Tan Xinqiang | Zendy; Shen Haigen | Zendy; Yu HaiZhu | Zendy; Li Chaozhong | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Selective Radical Fluorination of Tertiary Alkyl Halides at Room Temperature

Author(s) -

Chen He,

Liu Zhonglin,

Lv Ying,

Tan Xinqiang,

Shen Haigen,

Yu HaiZhu,

Li Chaozhong

Publication year - 2017

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201708197

Subject(s) - alkyl , selectfluor , halide , chemistry , halogen , acetonitrile , halocarbon , organic chemistry , halogenation , primary (astronomy) , photochemistry , catalysis , physics , astronomy

Direct fluorination of tertiary alkyl bromides and iodides with Selectfluor is described. The halogen‐exchange fluorination proceeds efficiently in acetonitrile at room temperature under metal‐free conditions and exhibits a wide range of functional group compatibility. Furthermore, the reactions are highly selective in that alkyl chlorides and primary and secondary alkyl bromides remain intact. A radical mechanism is proposed for this selective fluorination.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research