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From Designing the Molecules of Life to Designing Life: Future Applications Derived from Advances in DNA Technologies
Author(s) -
Kohman Richie E.,
Kunjapur Aditya M.,
Hysolli Eriona,
Wang Yu,
Church George M.
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201707976
Subject(s) - computational biology , genome , oligonucleotide , nanotechnology , dna , dna sequencing , computer science , genome editing , data science , biology , genetics , gene , materials science
Since the elucidation of its structure, DNA has been at the forefront of biological research. In the past half century, an explosion of DNA‐based technology development has occurred with the most rapid advances being made for DNA sequencing. In parallel, dramatic improvements have also been made in the synthesis and editing of DNA from the oligonucleotide to the genome scale. In this Review, we will summarize four different subfields relating to DNA technologies following this trajectory of smaller to larger scale. We begin by talking about building materials out of DNA which in turn can act as delivery vehicles in vivo. We then discuss how altering microbial genomes can lead to novel methods of production for industrial biologics. Next, we talk about the future of writing whole genomes as a method of studying evolution. Lastly, we highlight the ways in which barcoding biological systems will allow for their three‐dimensional analysis in a highly multiplexed fashion.