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Unsymmetrical Biaryl Compounds: Metal‐ and Reagent‐Free Electrochemical Couplings Are on the Advance
Author(s) -
Schäfer Hans J.
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201707804
Subject(s) - reagent , electrochemistry , aryl , chemistry , anode , electrolyte , combinatorial chemistry , supporting electrolyte , solvent , electrode , boron , metal , inorganic chemistry , diamond , organic chemistry , alkyl
It's electrifying ! Electrochemical cross‐coupling of aryl compounds provides a one‐step approach to unsymmetrical biaryl compounds. A boron‐doped diamond electrode is used as the anode to oxidise the phenolic hydroxy group to a phenoxy radical, with 1,1,1,3,3,3‐hexafluoroisopropylalcohol (HFIP) and tetraalkylammonium methylsulfate used as the solvent and electrolyte. Since no reagents are required, no waste is formed from this source.