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A Smart Metal–Organic Framework Nanomaterial for Lung Targeting
Author(s) -
SimonYarza Teresa,
GiménezMarqués Mónica,
Mrimi Rhizlaine,
Mielcarek Angelika,
Gref Ruxandra,
Horcajada Patricia,
Serre Christian,
Couvreur Patrick
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201707346
Subject(s) - lung , drug delivery , drug , human lung , nanotechnology , chemistry , nanomaterials , medicine , biomedical engineering , pharmacology , materials science
Despite high morbidity and mortality associated with lung diseases, addressing drugs towards lung tissue remains a pending task. Particle lung filtration has been proposed for passive lung targeting and drug delivery. However, toxicity issues derived from the long‐term presence of the particles must be overcome. By exploiting some of the ignored properties of nanosized metal–organic frameworks it is possible to achieve impressive antitumoral effects on experimental lung tumors, even without the need to engineer the surface of the material. In fact, it was discovered that, based on unique pH‐responsiveness and reversible aggregation behaviors, nanoMOF was capable of targeting lung tissue. At the neutral pH of the blood, the nanoMOFs form aggregates with the adequate size to be retained in lung capillaries. Within 24 h they then disaggregate and release their drug payload. This phenomenon was compatible with lung tissue physiology.