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Copper‐Catalyzed Borylacylation of Activated Alkenes with Acid Chlorides
Author(s) -
Huang Yuan,
Smith Kevin B.,
Brown M. Kevin
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201707323
Subject(s) - alkene , catalysis , copper , chemistry , vinyl chloride , alkyl , chloride , organic chemistry , inorganic chemistry , copolymer , polymer
A method for the copper‐catalyzed borylacylation of activated alkenes is presented. The reaction involves borylcupration of the alkene, followed by capture of the generated alkyl–copper intermediate with an acid chloride. The reactions operated with low catalyst loading and generally occurre within 15 min at room temperature for a range of activated alkenes. In the case of vinyl arenes, enantioselective borylacylation was possible.