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Cover Picture: Diazirines as Potential Molecular Imaging Tags: Probing the Requirements for Efficient and Long‐Lived SABRE‐Induced Hyperpolarization (Angew. Chem. Int. Ed. 40/2017)
Author(s) -
Shen Kun,
Logan Angus W. J.,
Colell Johannes F. P.,
Bae Junu,
Ortiz Gerardo X.,
Theis Thomas,
Warren Warren S.,
Malcolmson Steven J.,
Wang Qiu
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201707296
Subject(s) - diazirine , hyperpolarization (physics) , chemistry , nanotechnology , nuclear magnetic resonance spectroscopy , stereochemistry , materials science
Diazirines are an attractive class of potential molecular tags for magnetic resonance imaging owing to their biocompatibility and ease of incorporation into a large variety of molecules. In their Communication on page 12112 ff., W. S. Warren, S. J. Malcolmson, Q. Wang, and co‐workers show with a 15 N 2 ‐diazirine‐containing choline derivative that 15 N 2 ‐diazirine motifs are capable of supporting long‐lasting polarization by the simple SABRE‐SHEATH hyperpolarization method, making then promising as tags for NMR/MRI imaging.