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Back Cover: Cyanide‐Free and Broadly Applicable Enantioselective Synthetic Platform for Chiral Nitriles through a Biocatalytic Approach (Angew. Chem. Int. Ed. 40/2017)
Author(s) -
Betke Tobias,
Rommelmann Philipp,
Oike Keiko,
Asano Yasuhisa,
Gröger Harald
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201707179
Subject(s) - enantioselective synthesis , nitrile , enantiomer , cyanide , chemistry , substrate (aquarium) , organic chemistry , stereochemistry , combinatorial chemistry , catalysis , biology , ecology
A cyanide‐free platform technology for the synthesis of chiral nitriles through biocatalytic enantioselective dehydration of a wide range of aldoximes leads to the nitrile products with high enantioselectivity in many cases. In their Communication on page 12361 ff., Y. Asano, H. Gröger, and co‐workers also describe an interesting phenomenon with regard to the enantiospecificity: Depending on whether the E or Z isomer of the racemic substrate is used, the other enantiomer of the nitrile is obtained with the same enzyme.