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Black Pigment Gallstone Inspired Platinum‐Chelated Bilirubin Nanoparticles for Combined Photoacoustic Imaging and Photothermal Therapy of Cancers
Author(s) -
Lee Dong Yun,
Kim Jin Yong,
Lee Yonghyun,
Lee Soyoung,
Miao Wenjun,
Kim Hyeon Sik,
Min JungJoon,
Jon Sangyong
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201707137
Subject(s) - photothermal therapy , nanomedicine , gallstones , cisplatin , cancer , cancer research , nanoparticle , chemistry , materials science , chemotherapy , nanotechnology , medicine
Bilirubin (BR), a bile pigment that exerts potent antioxidant and anti‐inflammatory effects, is also a major constituent of black pigment gallstones found in bile ducts under certain pathological conditions. Inspired by the intrinsic metal‐chelating power of BR found in gallstones, herein we report a cisplatin‐chelated BR‐based nanoparticle (cisPt@BRNP) for use as a new photonic nanomedicine for combined photoacoustic imaging and photothermal therapy of cancers. The cisPt@BRNPs were prepared by simply mixing cisplatin with BRNPs, yielding ca. 150‐nm‐size NPs. Upon near‐IR laser irradiation at 808 nm, cisPt@BRNPs generated considerable heat and induced clear death of cancer cells in vitro. Following intravenous injection into human colon cancer‐bearing mice, cisPt@BRNPs allowed effective tumor visualization by photoacoustic imaging and remarkable antitumor efficacy by photothermal therapy, suggesting their potential for use as a new photonic nanomedicine for cancer therapy.