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Degradable Vanadium Disulfide Nanostructures with Unique Optical and Magnetic Functions for Cancer Theranostics
Author(s) -
Chen Yuyan,
Cheng Liang,
Dong Ziliang,
Chao Yu,
Lei Huali,
Zhao He,
Wang Jian,
Liu Zhuang
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201707128
Subject(s) - nanomedicine , photothermal therapy , polyethylene glycol , nanoparticle , materials science , peg ratio , nanodot , nanotechnology , absorbance , chemistry , organic chemistry , finance , economics , chromatography
Abstract Multifunctional biodegradable inorganic theranostic nano‐agents are of great interest to the field of nanomedicine. Upon lipid modification, VS 2 nanosheets could be converted into ultra‐small VS 2 nanodots encapsulated inside polyethylene glycol (PEG) modified lipid micelles. Owing to paramagnetism, high near‐infrared (NIR) absorbance, and chelator‐free 99m Tc 4+ labeling of VS 2 , such VS 2 @lipid‐PEG nanoparticles could be used for T1‐weighted magnetic resonance (MR), photoacoustic (PA),and single photon emission computed tomography (SPECT) tri‐modal imaging guided photothermal ablation of tumors. Importantly, along with the gradual degradation of VS 2 , our VS 2 @lipid‐PEG nanoparticles exhibit effective body excretion without appreciable toxicity. The unique advantages of VS 2 nanostructures with highly integrated functionalities and biodegradable behaviors mean they are promising for applications in cancer theranostics.