Regioselective Intermolecular Allylic C−H Amination of Disubstituted Olefins via Rhodium/π‐Allyl Intermediates | Zendy

Burman Jacob S. | Zendy; Blakey Simon B. | Zendy

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Regioselective Intermolecular Allylic C−H Amination of Disubstituted Olefins via Rhodium/π‐Allyl Intermediates

Author(s) -

Burman Jacob S.,

Blakey Simon B.

Publication year - 2017

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201707021

Subject(s) - regioselectivity , allylic rearrangement , amination , chemistry , rhodium , intermolecular force , nucleophile , catalysis , alkyl , styrene , medicinal chemistry , organic chemistry , molecule , copolymer , polymer

A method for catalytic intermolecular allylic C−H amination of trans ‐disubstituted olefins is reported. The reaction is efficient for a range of common nitrogen nucleophiles bearing one electron‐withdrawing group, and proceeds under mild reaction conditions. Good levels of regioselectivity are observed for a wide range of electronically diverse trans ‐β‐alkyl styrene substrates.

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