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Regioselective Intermolecular Allylic C−H Amination of Disubstituted Olefins via Rhodium/π‐Allyl Intermediates
Author(s) -
Burman Jacob S.,
Blakey Simon B.
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201707021
Subject(s) - regioselectivity , allylic rearrangement , amination , chemistry , rhodium , intermolecular force , nucleophile , catalysis , alkyl , styrene , medicinal chemistry , organic chemistry , molecule , copolymer , polymer
A method for catalytic intermolecular allylic C−H amination of trans ‐disubstituted olefins is reported. The reaction is efficient for a range of common nitrogen nucleophiles bearing one electron‐withdrawing group, and proceeds under mild reaction conditions. Good levels of regioselectivity are observed for a wide range of electronically diverse trans ‐β‐alkyl styrene substrates.