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Flavylium Polymethine Fluorophores for Near‐ and Shortwave Infrared Imaging
Author(s) -
Cosco Emily D.,
Caram Justin R.,
Bruns Oliver T.,
Franke Daniel,
Day Rachael A.,
Farr Erik P.,
Bawendi Moungi G.,
Sletten Ellen M.
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201706974
Subject(s) - infrared , near infrared spectroscopy , brightness , photochemistry , materials science , characterization (materials science) , micelle , optoelectronics , wavelength , chemistry , optics , nanotechnology , physics , aqueous solution
Bright fluorophores in the near‐infrared and shortwave infrared (SWIR) regions of the electromagnetic spectrum are essential for optical imaging in vivo. In this work, we utilized a 7‐dimethylamino flavylium heterocycle to construct a panel of novel red‐shifted polymethine dyes, with emission wavelengths from 680 to 1045 nm. Photophysical characterization revealed that the 1‐ and 3‐methine dyes display enhanced photostability and the 5‐ and 7‐methine dyes exhibit exceptional brightness for their respective spectral regions. A micelle formulation of the 7‐methine facilitated SWIR imaging in mice. This report presents the first polymethine dye designed and synthesized for SWIR in vivo imaging.