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Copper‐Catalyzed Synthesis and Applications of Yndiamides
Author(s) -
Mansfield Steven J.,
Christensen Kirsten E.,
Thompson Amber L.,
Ma Kai,
Jones Michael W.,
Mekareeya Aroonroj,
Anderson Edward A.
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201706915
Subject(s) - alkyne , catalysis , copper , nucleophile , combinatorial chemistry , chemistry , transition metal , coupling (piping) , nitrogen , metal , organic chemistry , materials science , metallurgy
Abstract The first synthetic route to yndiamides, a novel class of double aza‐substituted alkyne, has been established by the copper(I)‐catalyzed cross‐coupling of 1,1‐dibromoenamides with nitrogen nucleophiles. The utility of these compounds is demonstrated in a range of transition‐metal‐catalyzed and acid‐catalyzed transformations to afford a wide variety of 1,2‐diamide functionalized products.