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Direct and Stereospecific [3+2] Synthesis of Pyrrolidines from Simple Unactivated Alkenes
Author(s) -
OteroFraga Jorge,
SuárezPantiga Samuel,
MontesinosMagraner Marc,
Rhein Dennis,
Mendoza Abraham
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201706682
Subject(s) - stereospecificity , catalysis , chemistry , organocatalysis , intermolecular force , organic synthesis , combinatorial chemistry , transition metal , enantioselective synthesis , simple (philosophy) , organic chemistry , computational chemistry , molecule , philosophy , epistemology
Pyrrolidines are important heterocyclic compounds with endless applications in organic synthesis, metal catalysis, and organocatalysis. Their potential as ligands for first‐row transition‐metal catalysts inspired a new method to access complex poly‐heterocyclic pyrrolidines in one step from available materials. This fundamental step forward is based on the discovery of an essential organoaluminum promoter that engages unactivated and electron‐rich olefins in intermolecular [3+2] cycloadditions.