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Response to Comment on “A Liposomal System Capable of Generating CO 2 Bubbles to Induce Transient Cavitation, Lysosomal Rupturing and Cell Necrosis”
Author(s) -
Wan WeiLin,
Chung MinFan,
Shih PoChien,
Sung HsingWen
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201706509
Subject(s) - liposome , cavitation , transient (computer programming) , aqueous solution , culprit , bicarbonate , ammonium bicarbonate , biophysics , chemistry , materials science , nanotechnology , computer science , physics , mechanics , biology , medicine , organic chemistry , raw material , myocardial infarction , operating system
Leroux et al. performed a set of experiments reported in our study and claim that they failed to reproduce the thermoresponsive liposomal system containing ammonium bicarbonate (ABC) that could trigger drug release under mild heating. We disagree with their assessments and speculate that the different method used by Leroux et al. to prepare the aqueous ABC is the culprit.