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Cover Picture: Structural Basis for Expansion of the Genetic Alphabet with an Artificial Nucleobase Pair (Angew. Chem. Int. Ed. 39/2017)
Author(s) -
Betz Karin,
Kimoto Michiko,
Diederichs Kay,
Hirao Ichiro,
Marx Andreas
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201706478
Subject(s) - nucleobase , base pair , alphabet , crystallography , chemistry , dna , crystal structure , chalcogen , stereochemistry , biochemistry , linguistics , philosophy
Expansion of the genetic alphabet … … with hydrophobic artificial base pairs is a promising approach. In their Communication on page 12000 ff., A. Marx, I. Hirao, and co‐workers present a high‐resolution crystal structure of the dDs–dPx pair in the active site of a DNA polymerase. They show that the artificial base pair adopts a planar structure just like a natural nucleobase pair. Its varying size and shape, however, cause minor alterations near the active site.