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Intermolecular Palladium‐Catalyzed Oxidative Fluorocarbonylation of Unactivated Alkenes: Efficient Access to β‐Fluorocarboxylic Esters
Author(s) -
Qi Xiaoxu,
Yu Feng,
Chen Pinhong,
Liu Guosheng
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201706401
Subject(s) - palladium , catalysis , intermolecular force , oxidative phosphorylation , chemistry , combinatorial chemistry , organic chemistry , molecule , biochemistry
A novel palladium‐catalyzed intermolecular oxidative fluorocarbonylation of alkenes has been developed, in which employment of a cooperative process with electrophilic ArIF 2 ‐meidated alkenes activation and palladium‐catalyzed carbonylation is crucial for the successful catalytic transformation. The current transformation presents the first convenient method to generate β‐fluorinated carboxylic acid derivatives under mild reaction conditions from simple alkenes with excellent regioselectivity.